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KMID : 0370220090530050241
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Yakhak Hoeji
2009 Volume.53 No. 5 p.241 ~ p.249
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Combination of Green Tea Extract and L-Theanine Alleviates Electric Foot Shock Induced Stress by Modulating Neurotransmitters in Mice
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Park Sang-Ki
Kim Tae-Il
Park Hyoung-Kook
Hong Jin-Tae
Lee Won-Kyung
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Abstract
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Various neurotransmitters are involved in regulating stress systems. In this study, we investigated the combination relieving effect of green tea extract(GTE) and L-theanine on the stress induced by electric foot shock. Four week oral administration of GTE (24 mg/kg), L-theanine (4 mg/kg) or their combination reduced the levels of dopamine, noradrenaline and corticosterone in blood, brain cortex, hippocampus, and striatum, wherease increased serotonin level. The combination of GTE and L-theanine showed much greater effects than single treatment of each component, and the effects are comparable to diazepam (2 mg/kg). Therefore, this study suggests that the combination of GTE and L-theanine may act effective and be useful for stress relieving treatment.
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KEYWORD
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green tea extract, L-theanine, anti-stress, neurotransmitter
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